Protein name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with INSIG1 (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLSRLFRMHG | LFVASHPWEV | IVGTVTLTIC | MMSMNMFTGN | NKICGWNYEC |
100:
PKLEEDVLSS | DIIILTITRC | IAILYIYFQF | QNLRQLGSKY | ILGIAGLFTI |
150:
FSSFVFSTVV | IHFLDKELTG | LNEALPFFLL | LVDLSRASAL | AKFALSSNSQ |
200:
DEVRENIARG | MAILGPTFTL | DALVECLVIG | VGTMSGVRQL | EIMCCFGCMS |
250:
VLANYFVFMT | FFPACVSLVL | ELSRESREGR | PIWQLSHFAR | VLEEEENKPN |
300:
PVTQRVKMIM | SLGLVLVHAH | SRWIADPSPQ | NSTADNSKVS | LGLDENVSKR |
350:
IEPSVSLWQF | YLSKMISMDI | EQVITLSLAL | LLAVKYIFFE | QAETESTLSL |
400:
KNPITSPVVT | QKKITDDCCR | RDPVLVRNDQ | KFHAMEEETR | KNRERKVEVI |
450:
KPLLAENDTS | HRATFVVGNS | SLLGTSLELE | TQEPEMELPV | EPRPNEECLQ |
500:
ILENAEKGAK | FLSDAEIIQL | VNAKHIPAYK | LETLMETHER | GVSIRRQLLS |
550:
KKLPEPSSLQ | YLPYRDYNYS | LVMGACCENV | IGYMPIPVGV | AGPLCLDGKE |
600:
FQVPMATTEG | CLVASTNRGC | RAIGLGGGAS | SRVLADGMTR | GPVVRFPRAC |
650:
DSAEVKAWLE | TPEGFTVIKE | AFDSTSRFAR | LQKLHMSVAG | RNLYIRFQSR |
700:
SGDAMGMNMI | SKGTEKALSK | LQEYFPEMQI | LAVSGNYCTD | KKPAAINWIE |
750:
GRGKSVVCEA | VIPAKVVREV | LKTTTEAMIE | VNINKNLVGS | AMAGSIGGYN |
800:
AHAANIVTAI | YIACGQDAAQ | NVGSSNCITL | MEASGPTNED | LYISCTMPSI |
850:
EIGTVGGGTN | LLPQQACLQM | LGVQGACRDN | PGENARQLAR | IVCGTVMAGE |
888:
LSLMAALAAG | HLVRSHMIHN | RSKINLQDLQ | GTCTKKAA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Pig
Mouse
Rabbit
ELISA Kit for Bovine HMG-CoA reductase
ELISA Kit for Bovine HMG-CoA reductase
ELISA Kit for Bovine HMG-CoA reductase
ELISA Kit for Bovine HMG-CoA reductase
ELISA Kit for Bovine HMG-CoA reductase
ELISA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
CLIA Kit for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Polyclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Monoclonal Antibody for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
Protein for Bovine HMG-CoA reductase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V.
,
Delcher A.L.
,
Florea L.
,
Kelley D.R.
,
Schatz M.C.
,
Puiu D.
,
Hanrahan F.
,
Pertea G.
,
Van Tassell C.P.
,
Sonstegard T.S.
,
Marcais G.
,
Roberts M.
,
Subramanian P.
,
Yorke J.A.
,
Salzberg S.L.
Genome Biol.10:R42.01-R42.10(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Hereford .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hippocampus .